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Research
Interests:
PhD research: Current analytical techniques to characterize angiogenesis,
arteriogenic vessel remodeling, and physiologic restoration of limb normoxia
in pre-clinical models of peripheral arterial disease are lacking due to one
or more shortcomings including: (1) lack of quantitative data, (2) user
subjectivity, (3) inadequate spatial resolution, (4) lack of longitudinal in
vivo imaging capability, (5) inability to simultaneously measure vessel
morphology and function, and (6) the requirement of multiple cohorts of mice
for time-course analyses. The goal of my research is to develop an optical,
intravital imaging technique that can acquire spatially co-registered,
high-resolution data sets on vessel morphology, blood flow, and blood
oxygenation. These optical images will be collected with a multi-functional
microscope that combines optical coherence tomography (OCT) and
hyperspectral imaging. This project is a collaboration between the Skala Lab
and the Duvall
Advanced Therapeutics Lab
Undergraduate research: In
2008 I studied the mechanosensory abilities of osteocytes in vitro in the lab of Dr. Jean X. Jiang at the University of Texas
Health Science Center at San Antonio. In 2009 I worked on a project
evaluating the potential for adipose-derived stem cells to promote recovery
of muscle function following tourniquet-induced ischemia-reperfusion injury.
This research was conducted in the lab of Dr. Thomas J. Walters at the U.S.
Army Institute for Surgical Research.
Publications
Journal Articles:
Burra S, Nicolella
DP, Francis WL, Freitas CJ, Mueschke NJ,
Poole K, and Jiang JX. “Dendritic
processes of osteocytes are mechanotransducers that induce the opening of
hemichannels.” PNAS 107, no. 31
(2010):13648-13653.
Conference abstracts:
Talks
Posters
Other publishings
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