Infrared Neural Stimulation in Humans
Studies by our group have demonstrated that infrared neural
stimulation has unique advantages over traditional electrical
stimulation in certain situations.
Contact and artifact free high spatial precision stimulation
would be advantageous in certain clinical situations, such as
mapping of nerves during tumor resection or providing better
frequency encoding in cochlea implants.
With these applications in mind, our group has performed the
first study to apply INS in humans.
In patients undergoing selective dorsal root rhizotomy, we
have shown that INS can activate dorsal roots with better spatial
precision than electrical stimulation.
No artifact was generated from INS and stimulation could be
achieved in a contact free method.
The results of this study have established the efficacy
needed to start additional clinical trials to improve upon current
standard of care where electrical stimulation has proven to be
Cayce JM, Wells JD, Malphrus JD, Kao CC,
Thomsen S, Tulipan NB, Konrad PE,
Jansen ED, Mahadevan-Jansen A. Advancing infrared neural stimulation towards use in humans. Nature
Feng HJ, Kao CC,
Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, MacDonald RL –
Alteration of GABAergic neurotransmission by pulsed infrared laser
stimulation – J Neural Engineering (in press).