Biomedical Optics

Anita Mahadevan-Jansen, Ph.D.

Assistant Professor of Biomedical Engineering Phone: (615) 343-4787 Email: mailing address: Vanderbilt University Station B Box 351631 Nashville, TN 37235 Physical Address: 5824 Stevenson Center Nashville, TN 37232

Description of Research Program

Current Projects

Recent Publications

Description of Research Program:

Dr. Mahadevan-Jansen joined the faculty of the Biomedical Engineering Department in the fall of 1998. Her expertise is in the area of optical diagnosis of clinical physiology and pathology. She has been working in the area of optical spectroscopy and imaging and specifically on the application of fluorescence and Raman spectroscopy for the diagnosis of cancers and precancers for the last eight years. She is part of the new Biomedical Optics laboratory and research program at Vanderbilt along with Dr. Duco Jansen. Together the Biomedical Optics research program in the Biomedical Engineering Department includes both therapeutic and diagnostic applications of lasers and light in medicine with approximately 2000 ft² of lab space dedicated for this research. Research in the diagnostic area is focused on 1) Optical spectroscopy and spectral imaging for intraoperative guidance, 2) Raman spectroscopy for ddisease detection in vivo, and 3) Optical techniques for stimulating and imaging electrical activity in nerves. In addition, Dr. Mahadevan-Jansen teaches several courses in Engineering including a graduate course in optical detection and co-teaches an undergraduate lecture and lab course in biomedical optics.

Current Projects Include:

1. Brain tumor demarcation using optical spectroscopy
2. Optical imaging for tissue differentiation in vivo
3. Development of Raman probes for clinical application of Raman spectroscopy
4. Raman spectroscopy for the diagnosis of cancers
5. Optical functional imaging

Recent Publications:

Lin WC, Toms SA, Motamedi M, Jansen ED, Mahadevan-Jansen A - Brain Tumor Demarcation using Optical Spectroscopy, Journal of Biomedical Optics, 5(2), April, 2000.

Lin WC, Toms SA, Jansen ED, Mahadevan-Jansen A, Intraoperative Spectroscopic-Guided Brain Tumor Resection, In: Biomedical Diagnostic, Guidance, and Surgical Assist Systems II , SPIE, 3911, Bellingham WA, 2000.

Lieber CA, Molpus K, Brader K, Mahadevan-Jansen A, Diagnostic tool for early detection of ovarian cancers using Raman spectroscopy, In: Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, SPIE, 3918, Bellingham, WA, 2000.

Mahadevan-Jansen A, Mitchell MF, Richards-Kortum R. Development of a Fiber Optic Probe to measure NIR Raman Spectra of Cervical Tissue in vivo, Photochemistry and Photobiology, 68(3), 427-431, 1998.

Mahadevan-Jansen A, Mitchell MF, Ramanujam N, Malpica A, Thomsen S, Richards-Kortum R. Near- Infrared Raman Spectroscopy for the Diagnosis of Cervical Precancers. Photochemistry and Photobiology, 68(1), 123-132, 1998.

Mahadevan-Jansen A, Richards-Kortum R. Raman Spectroscopy for the Detection of Cancers and Precancers. Journal of Biomedical Optics, 1(1), 40-79, 1996  

Mahadevan A, Mitchell MF, Silva ES, Thomsen S, Richards-Kortum R. Study of the Fluorescence Properties of Normal and Neoplastic Human Cervical Tissue. Lasers in Medicine and Surgery, 13, 647-655, 1993.

Ramanujam N, Li Y, Richards-Kortum R, Mahadevan-Jansen A, Thomsen S, Mitchell MF, Jenkins T, Chance B. Relationship between cellular metabolism and intra-vascular oxygenation using low temperature spectrophotometry, Photochemistry and Photobiology, (submitted for publication), 1998.

Ramanujam N, Mitchell MF, Mahadevan-Jansen A, Thomsen S, Staerkel G, Malpica A, Wright T, Atkinson A, Richards-Kortum R. Cervical Precancer Detection Using a Multivariate Statistical Algorithm Based on Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths, Photochemistry and Photobiology, 64(4), 720-735, 1996.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson A, Richards-Kortum R. Development of a Multivariate Statistical Algorithm to Analyze Human Cervical Tissue Fluorescence Spectra Acquired In Vivo, Laser in Surgery and Medicine, 19(1), 46-62, 1996.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Wright T, Atkinson A, Richards-Kortum R. Spectroscopic Diagnosis of Cervical Intraepithelial Neoplasia (CIN) In Vivo using Laser-Induced Fluorescence Spectra at Multiple Excitation Wavelengths, Laser in Surgery and Medicine, 19(1), 63-74, 1996.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum R. Fluorescence Spectroscopy: A Diagnostic Tool for Cervical Intraepithelial Neoplasia, Chapter 10: Female Genital Tract, In: Year Book of Pathology and Laboratory Medicine, Editors: Mill ED, Burns DE, Stoler MH, Mosby, Chicago, 1995.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Richards-Kortum R. Diagnosis of Cervical Intraepithelial Neoplasia using a Two-Stage Algorithm: A Prospective Study, Obstetrics and Gynecology, (submitted for publication), 1995

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Malpica A, Richards-Kortum R. Composite Algorithms for the Differential Diagnosis of Cervical Precancers, Applied Spectroscopy, (submitted for publication), 1995

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum R. Fluorescence Spectroscopy: a Diagnostic Tool for Cervical Intraepithelial Neoplasia (CIN). Gynecologic Oncology, 52, 31-38, 1994.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Richards-Kortum R. In Vivo Diagnosis of Cervical Intraepithelial Neoplasia (CIN) using 337 nm Laser Induced Fluorescence, Proceedings of National Academy of Science, 91, 10193-10197, 1994.

Ramanujam N, Mitchell MF, Mahadevan A, Thomsen S, Silva E, Richards-Kortum R. Fluorescence Spectroscopy of the Cervix, Clinical Consultations in Obstetrics and Gynecology, 6(1), 62-69, 1994.