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Biomedical Modeling Laboratory

Michael I. Miga, Ph.D.

Assistant Professor of Biomedical Engineering

Phone: 615-343-8336
Email:

mailing address:
Vanderbilt University Station B
Box 351631
Nashville, TN 37235

Physical/Shipping Address:
5923 Stevenson Center
Nashville, TN 37232

Description of Research Program

Current Projects

Recent Publications

Description of Research Program:

Dr. Miga joined the faculty of the Biomedical Engineering Department in the fall of 2000. His expertise is in the area of numerical methods and biomedical modeling and is currently the director of the Biomedical Modeling Laboratory (http://bmlweb.vuse.vanderbilt.edu).  The focus of the Biomedical Modeling Laboratory is on developing new paradigms in detection, diagnosis and treatment of disease through the integration of computational models into clinical decision-making practices.  He teaches courses in numerical methods, computational modeling for biomedical applications, and biomechanics.

Current Projects Include:

1.Brain deformation modeling in the context of image-guided surgery

2.Co-registered ultrasonography for use in image-guided surgery

3.Novel registration algorithms using surface-based data and mutal information

4.Inverse problems in elastography and seizure source detection
 

Recent Publications:

1.  M. I. Miga, K. D. Paulsen, J. M. Lemry, F. E. Kennedy, S. D. Eisner, A. Hartov, D. W. Roberts, ‘Model-updated image guidance: Initial clinical experience with gravity-induced brain deformation’, IEEE Transactions on Medical Imaging, Vol. 18, No. 10, pp. 866-874, 1999.

 2.  D. W. Roberts, M. I. Miga, S. D. Eisner, A. Hartov , J. Lemry, F. E. Kennedy, K. D. Paulsen, ‘Intraoperative updated neuroimaging using brain modeling and sparse data’, Neurosurgery, Vol. 45, No. 5, pp. 1199-1207, 1999.

 3.  M. I. Miga, K. D. Paulsen, F. E. Kennedy, A. Hartov, D. W. Roberts, ‘Model-updated image-guided neurosurgery using the finite element method: Incorporation of the falx cerebri’, Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 1999, Springer Verlag, New York, Vol. 1679, pp. 900-909, 1999.

 4.  M. I. Miga, K. D. Paulsen, P. J. Hoopes, F. E. Kennedy, A. Hartov, D. W. Roberts, ‘In vivo analysis and modeling of interstitial pressure in the brain under surgical loading’, ASME Journal of Biomechanical Engineering, Vol. 122, No. 4, pp. 354-363, 2000.

 5.  E. E. W. Van Houten, J. B. Weaver, M. I. Miga, F. E. Kennedy, K. D. Paulsen, 'Elasticity reconstruction from experimental MR displacement data:  Initial experience with an overlapping subzone finite element inversion process', Medical Physics, Vol. 27, No. 1, pp. 101-107, 2000.

 6.  M. I. Miga, K. D. Paulsen, P. J. Hoopes, F. E. Kennedy, A. Hartov, D. W. Roberts, ‘In-vivo analysis of heterogeneous brain deformation computations for model-updated image guidance’, Computer Methods in Biomechanics and Biomedical Engineering , Vol. 3, No. 2, pp. 129-146, 2000.

 7.  M. I. Miga, K. D. Paulsen, P. J. Hoopes, F. E. Kennedy, A. Hartov, D. W. Roberts, ‘In vivo quantification of a homogeneous brain deformation model for updating preoperative images during surgery’, IEEE Transactions on Biomedical Engineering, Vol. 47, No.2, pp. 266-273, 2000.

 8.  M. I. Miga, A. Staubert, K. D. Paulsen, F. E. Kennedy, V. M. Tronnier, D. W. Roberts, A. Hartov, L. A. Platenik, K. E. Lunn, `Model-updated image-guided neurosurgery: Preliminary analysis using intraoperative MR', Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2000, Springer Verlag, New York, Vol. 1935, pp. 115-124, 2000.

 9.  M. I. Miga, D. W. Roberts, F. E. Kennedy, L. A. Platenik, A. Hartov, K. E. Lunn, K. D. Paulsen, 'Computational Modeling of Retraction and Resection for Updating Images During Surgery', Neurosurgery, Vol. 49, No. 1, pp. 75-84, 2001.

 10.  P. M. Meaney, K. D. Paulsen, B. W. Pogue, M. I. Miga, ‘Microwave image reconstruction utilizing log-magnitude and unwrapped phase to improve high-contrast object recovery’, IEEE Trans. on Medical Imaging, Vol. 20, No. 2, pp. 104-116, 2001.

 11.  E. E. W. Van Houten, M. I. Miga, J. B. Weaver, F. E. Kennedy, K. D. Paulsen, ‘Three-dimensional subzone-based reconstruction algorithm for MR elastography’, Magnetic Resonance in Medicine, Vol. 45, No. 5, pp. 827-837, 2001

 12.  J. B. Weaver, E. E. W. Van Houten, M. I. Miga, F. E. Kennedy, K. D. Paulsen, ‘Magnetic resonance elastography using 3D gradient echo measurements of steady-state motion’, Medical Physics, vol. 28, no. 8, pp.1620-1628, 2001.

 13.  M. I. Miga, T. E. Kerner, T. M. Darcey, ‘Source localization using finite elements and targeted simulated annealing’, IEEE Trans. on Biomedical Engineering, vol. 49, no. 7, pp. 743-745, 2002. 

14.  T. K. Sinha, D. M. Cash, R. J. Weil, R. L. Galloway, M. I. Miga, ‘Cortical surface registration using texture mapped point clouds and mutual information’, Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2002, Springer Verlag, New York, Vol. 2488, Part 2, pp. 533-540, 2002.

 15.  L. A. Platenik, M. I. Miga, D. W. Roberts, K. E. Lunn, F. E. Kennedy, A. Hartov, K. D. Paulsen,`In Vivo quantification of retraction deformation modeling for updated image-guidance during neurosurgery', IEEE Trans. on Biomedical Engineering, vol. 49, no. 8, pp. 823-835, 2002.

 16.  M. I. Miga, ‘A new approach to elastography using mutual information and finite elements’, Physics in Medicine and Biology, vol. 48, no. 4, pp. 467-480, 2003.

 17.  D. M. Cash, T. K. Sinha, W. C. Chapman, H. Terawaki, B. M. Dawant, R. L. Galloway, M. I. Miga, ‘Incorporation of a laser range scanner into image-guided liver surgery: surface acquisition, registration, and tracking’, Medical Physics, vol. 30, no. 7., pp. 1671-1682, 2003.

 18.  M. I. Miga, T. K. Sinha, D. M. Cash, R. L. Galloway, and R. J. Weil, ‘Cortical surface registration for image-guided neurosurgery using laser-range scanning’, IEEE Transactions on Medical Imaging, vol. 22, no. 8, pp.973-985, 2003.

 19.  V. Duay, T. K. Sinha, P. D’Haese, M. I. Miga, B. M. Dawant, ‘Non-rigid registration of serial intra-operative images for automatic brain-shift estimation’, Lecture Notes in Computer Science: Biomedical Image Registration, Springer Verlag, New York, Vol. 2717, pp. 61-70, 2003.

 20.  T. K. Sinha, V. Duay, B. M. Dawant, M. I. Miga, ‘Cortical shift tracking using a laser range scanner and deformable registration methods’, Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2003, Vol. 2879, Part 2, pp. 166-174, 2003.

 21.  P. Dumpuri, R. C. Chen, and M. I. Miga, ‘Model updated image guidance: A statistical approach’, Lecture Notes in Computer Science: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2003, Vol. 2878, Part 1, pp. 375-382, 2003.

 22.  C. W. Washington, and M. I. Miga, ‘Modality Independent Elastography (MIE):  A New Approach to Elasticity Imaging’, IEEE Transactions on Medical Imaging, vol. 23, no. 9, pp. 1117-1128, 2004.

 23.  T. K. Sinha, B. M. Dawant, V. Duay, D. M. Cash, R. J. Weil, and M. I. Miga, ‘A method to track cortical surface deformations using a laser range scanner’, IEEE Transactions on Medical Imaging, vol. 24, no. 6, pp. 767-781, 2005.

 24.  D. M. Cash, M. I. Miga, T. K. Sinha, R. L. Galloway, and W. C. Chapman, ‘Compensating for intra-operative soft tissue deformations using incomplete surface data and finite elements’, IEEE Transactions on Medical Imaging, (accepted), 2005.

 25.  M. I. Miga, M. P. Rothney, J. Ou, ‘Modality Independent Elastography (MIE):  Potential applications in Dermoscopy’, Medical Physics, vol. 32, no. 5, pp. 1308-1320, 2005.

 26. T. K. Sinha, M. I. Miga, D. M. Cash, and R. J. Weil, 'Intraoperative cortical surface characterization using laser range scanning: Preliminary results', Neurosurgery, Vol. 59, No. 4, pp. 368-377, 2006. 

 27. S. L. Barnes, A. Lyshchik, M. K. Washington, J. C. Gore, and M. I. Miga, 'Development of a mechanical testing assay for fibrotic murine liver', Medical Physics, Vol. 34, No. 11, pp. 4439-4450, 2007.

 28. C. R. Chen, M. I. Miga, R. L. Galloway, 'Characterization of tracked radiofrequency ablation in phantom', Medical Physics, Vol. 34, No. 10, pp. 4030-4040, 2007.

 29. D. M. Cash, M. I. Miga, S. C. Glasgow, B. M. Dawant, L. W. Clements, Z. Cao, R. L. Galloway, W. C. Chapman, 'Concepts and preliminary data toward the realization of image-guided liver surgery', Journal of Gastrointestinal Surgery, Vol. 11, No. 7, pp. 844-859, 2007.

 30. A. Lyshchik, R. Moses, S. L. Barnes, T. Higashi, R. Asato, M. I. Miga, J. C. Gore, A. C. Fleischer 'Quantitative analysis of tumor vascularity in benign and malignant solid thyroid nodules', Journal of Ultrasound in Medicine, Vol. 26, pp. 837-846, 2007.

 31. P. Dumpuri, R. C. Thompson, B. M. Dawant, A. Cao, M. I. Miga, 'An atlas-based method to compensate for brain shift: Preliminary results', Medical Image Analysis, Vol. 11, No. 2., pp.128-145, 2007.

 32. J. J. Ou, R. E. Ong, T. E. Yankeelov, and M. I. Miga, 'Evaluation of 3D modality-independent elastography for breast imaging: a simulation study', Physics in Medicine and Biology, Vol. 53, No. 1, pp. 147-163, 2008.

  BOOK CHAPTERS:

 K. D. Paulsen, and M. I. Miga, ‘Chapter 15:  Biomechanical modeling for image registration:  Applications in image-guided neurosurgery’,  Medical Image Registration, by editors:  J. V. Hajnal, D. L. G. Hill, and D. J. Hawkes, CRC Press, pp. 332- 362, 2001.

 M. I. Miga, T. K. Sinha, and D. M. Cash ‘Techniques to Correct for Soft Tissue Deformations during Image-Guided Brain Surgery’,  Biomechanics Applied to Computer Assisted Surgery, by editor: Yohan Payan, Research Signpost Publications, (in press), 2005.  

  

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