Physiological Transport PhenomenaRobert J. Roselli, Ph.D.
Description of Research Program Description of Research Program: Dr. Roselli's research interests are in two primary areas: transport phenomena in living systems and engineering education. In the area of biotransport, Dr. Roselli's work is directed toward understanding the mechanics of fluid and macromolecular solute exchange in the lung and in endothelial cell monolayers. Of particular interest is the role of molecular charge of the microvascular barrier and the solutes on regulating fluid and macromolecular exchange. Once these mechanisms are fully understood, it should be possible to predict conditions when pulmonary edema is likely to occur, and to either prevent its occurrence or to reverse the process once it has started. Dr. Roselli is also interested in the development of new minimally invasive clinical methods for measuring fluid and macromolecular transport in the lung. In the area of Engineering Education, Dr. Roselli has been a pioneer in the development of challenge-based learning modules. He has developed complete undergraduate courses in biomechanics and biotransport which are based on the principles laid out in the NRC report entitled "How People Learn." He has conducted research aimed at testing the effectiveness of challenge-based learning, an interactive classroom communication system, and other in-class activities. He has also developed a Free Body Diagram Tool which provides online assistance to students as they construct free body diagrams. He is currently developing online diagnostic learning modules which provide feedback to students while they are working homework problems. He is writing an introductory biotransport textbook with Dr. Kenn Diller at the University of Texas, Austin, which includes sections on challenge-based learning.Available Projects Include: Biotransport: 1. Development of theoretical models which describe the movement of fluid and macromolecular solutes through the microvascular barrier. 2. Theoretical and experimental methods for assessing the role of electrical charge in the movement of fluid, dextrans, dendrimers, and proteins through the microvascular barrier and methods for effectively separating macromolecules according to their molecular charge and molecular weight. 3. Development of non-invasive experimental methods for assessing lung microvascular permeability to macromoleucles. 4. Development of models describing fluid and solute exchange in the pleural space.
Education: 1. Using the VaNTH Courseware Authoring and Packaging Environment (CAPE) to develop a general data-driven diagnostic module that can be used to assist students as they attempt to solve engineering problems. 2. Development of courseware modules that integrate the delivery features of CAPE with the computational and graphical features of Matlab. 3. Use of CAPE to develop diagnostic tools that guide students as they attempt to simply complex partial differential equations, such as the Navier-Stokes equation, for specific problems. 4. Development of data mining strategies for CAPE modules that allow identification of students who need help and methods for providing them with the assistance needed. Recent Publications, Education: Roselli, RJ, Howard, L and Brophy S. Integration of formative assessment into online engineering assignments. Computers in Education Journal. In press, 2006. Roselli, RJ, Howard, L and Brophy, S. A computer-based free body diagram assistant. Computer Applications in Engineering Education. in press, 2006. Roselli, RJ and Brophy, S. Experiences with formative assessment in engineering classrooms. J. Engineering Education. In press, 2006. Roselli, RJ and Brophy, SP. Effectiveness of challenge-based instruction in biomechanics. J. Engineering Education. In press, 2006. Roselli, RJ and Howard. Facilitating the design of diagnostic learning modules with CAPE. Paper 2006-1199, ASEE Conference, Chicago, June, 2006. Barr, R., Pandy, M., Petrosino, A., Roselli, R., Brophy, S., and Freeman, R. The VaNTH Biomechanics Learning Modules. Proc ASEE/AaeE 4th Global Colloquium, 23 pages, 2005. Diller, K.R., Roselli, R.J., Martin, H.T. Teaching bioheat transfer based on "How People Learn" methodology. Proc IMECE 2004, IMECE2004-61486, 9 pages, 2004. Roselli, R.J. Challenge-Based Instruction in Biotransport. Proceedings of the 2004 ASEE Annual Conference, (CD-ROM DEStech Publications) Session 1309: 11 pages, 2004. Roselli, R.J. and Brophy, S.P. Redesigning a biomechanics course using challenge-based instruction. IEEE Engineering in Medicine and Biology Magazine 22:66-70, 2003. Klein, S.S. and Roselli, R.J. The iron cross. ASME Pre College Best Practice in High School Engineering, 8 pages, best paper award, 2003. Bransford, J.D, Vye, N, Bateman, H, Brophy, S. P. and Roselli, R. J. "Vanderbilt's AMIGO3 Project: Knowledge of How People Learn Enters Cyberspace." In Learner centered theory and practice in distance education: Case studies, T. Duffy and J. Kirkley, eds , Lawrence Erlbaum and Associates, Mahwah, NJ., 2003. Roselli, RJ, Howard LP, Cinnamon, B, Brophy, SP, Norris, PR, Rothney, MP and Eggers, D. Integration of an Interactive Free Body Diagram Assistant with a Courseware Authoring Package and an Experimental Learning Management System. ASEE Annual Conference, (CD-ROM DEStech Publications) Session 2793: 10 pages, 2003. Rothney, MP, Roselli, RJ and Howard LP. Creation of an online vector addition tutorial: Exploring the advantages of providing diagnostic, multilevel feedback in basic skills remediation, ASEE Annual Conference, (CD-ROM DEStech Publications) Session 2793: 7 pages, 2003. Roselli, RJ and Brophy, SP. Exploring an electronic polling system for the assessment of student progress in two biomedical engineering courses. ASEE Annual Conference, (CD-ROM DEStech Publications) Session 2609: 11 pages, 2002.
Recent Publications, Biotransport: Banks G., Roselli RJ, Chen, R. and Giorgio TD,. A model for the analysis of nonviral gene therapy. Gene Therapy, 10:1766-1775, 2003. Sanders, J.R., Pou N.A., and Roselli, R.J. Neutral and DEAE dextrans as tracers for pulmonary microvascular barrier permeability and integrity. J Appl Physiol. 93(1):251-62, 2002 Koizumi, T., Roselli, R.J., Parker, R.E., Hermo, C.I., Banerjee, M, and Newman, J.H. Clearance of filtered fluid from the lung during exercise: role of hyperpnea. Am J Respir Crit Care Med. 163(3 Pt 1):614-8, 2001. Nau, W.H., Milam, D.F, Roselli, R.J. and Smith, J.A. Principles of Laser Therapy. Chapter 16 In Benign Prostatic Hyperplasia, Ed. by P. Narayan. Churchill Livingstone, London, pp. 221-229, 2000. Nau, W.H., Roselli, R.J., and Milam, D.L. Measurement of thermal effects on the optical properties of prostate tissue at wavelengths of 1064 and 633 nm. Lasers in Surgery and Medicine, 24:38-47,1999. Caruthers, S.D., Paschal, C.B., Pou, N.A., Roselli, R.J., and Harris, T.R. Regional measurements of pulmonary edema using magnetic resonance imaging. J. Appl. Physiol., 84:2143-2153, 1998. Klaesner,J.W., Pou, N.A., Parker, R.E., Finney, C., and Roselli, R.J. Optical measurement of isolated canine lung filtration coefficients after alloxan infusion. J. Appl. Physiol., 84:1381-1387, 1998. Klaesner, J.W., Pou, N.A., Parker, R.E., Finney, C. and Roselli, R.J. Optical measurement of isolated canine lung filtration coefficients at normal hematocrits. J. Appl. Physiol. 83: 1976-1985, 1997. Roselli, R.J., Tack, G. and Harris, T.R. A model of fluid, erytrocyte, and solute transport in the lung. Ann. Biomed. Engin., 25: 46-61, 1997.
Klaesner,J.W., Pou, N.A., Parker, R.E., Galloway,
R.L., and Roselli, R.J. Laser system for measuring
small changes in plasma tracer concentration.
Biomedical Instrumentation and Technology
30:507-516,1996.
|
Copyright
© 2006
Vanderbilt University.
For more information, please contact the
webmaster.